327 Transition from Cough Variant Asthma to Asthma With Reduced FEV1

of asthma. No subject was assuming drugs or had suffered from respiratory infections in the last month. All subjects had normal lung function tests. With HViso 10 subjects had EI-B and 12 had EI-VCD. With HVhypo 8 subjects had EI-B and 15 EI-VCD. Eighteen subiects (49%) had Ddef (serum 25hydroxycholecalcipherol , 25 ng/mL). Serum levels of vitamin D were significantly lower in athletes with than in those without EI-VCD, either with HViso (19.1 6 1.8 vs 25.7 6 1.5 ng/mL; P 1⁄4 0.013) or with HVhypo (20.2 6 1.9 vs 26.2 6 1.8 ng/mL; P 1⁄4 0.029). No influence of vitamin D on EI-B could be demonstrated. Vitamin D levels were significantly related to the decrease in MIF50 (as % of baseline) during the test (HViso: r 1⁄4 0.41; P , 0.015 and HVipo: r 1⁄4 0.42; P 1⁄4 0.017). Conclusions: Our young athletes had a high prevalence of paradoxical vocal cord adduction during HV, which was strongly associated to Ddef. The high prevalence of Ddef was expected, since the study was conducted during winter in a town located beyond 458 latitude. Vitamin D deficiency may favour laryngospasm by decreasing calcium availability, ATP production and Ca-ATPase pump activity in the striate muscle cell, with consequent tetanic contraction and delayed relaxation. The fact that alkalosis worsens hypocalcemia accounts for the higher prevalence of laryngospasm observed during HVhypo.